Drug Name

Probalan (Probenecid)

Drug Uses

Probalan is used in the treatment of chronic gout or gouty arthritis. These conditions are caused by too much uric acid in the blood.

How to use

Use Probalan as directed by your doctor.

• Take Probalan tablets by mouth.
• Swallow the tablets with a drink of water.
• Take your doses at regular intervals.

Drug Class and Mechanism

Probalan works by removing the extra uric acid from the body. Probalan does not cure gout, but after you have been taking it for a few months it will help prevent gout attacks. Probalan will help prevent gout attacks only as long as you continue to take it.

Probalan is also used to prevent or treat other medical problems that may occur if too much uric acid is present in the body.

Probalan is sometimes used with certain kinds of antibiotics to make them more effective in the treatment of infections.

Missed Dose

If you miss a dose of Probalan, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Storage

Store Probalan at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Keep Probalan out of the reach of children and away from pets.

Warnings/Precautions

Do not use Probalan if:

• you are allergic to any ingredient in Probalan;
• you have blood problems or kidney stones caused by uric acid;
• the patient is a child younger than 2 years of age;
• you are taking salicylates (e.g., aspirin).

• Probalan may cause dizziness. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to Probalan. Using Probalan alone, with certain other medicines, or with alcohol may lessen your ability to drive or perform other potentially dangerous tasks.
• Before you have any medical or dental treatments, emergency care, or surgery, tell the doctor or dentist that you are using Probalan.
• Diabetes patients - Probalan may affect your blood sugar. Check blood sugar levels closely and ask your doctor before adjusting the dose of your diabetes medicine.
• Probalan may interfere with some lab tests (e.g., blood or hemoglobin urine tests, theophylline levels). Make sure your doctor and lab personnel know you are using Probalan.
• Lab tests, including tests for sugar in the urine, may be required to monitor your progress. Be sure to keep all doctor and lab appointments.
• Use of Probalan is not recommended in children younger than 2 years of age. Safety and effectiveness in this age group have not been confirmed.
• Pregnancy and breast-feeding: If you become pregnant while taking Probalan, discuss with your doctor the benefits and risks of using Probalan during pregnancy. Probalan is excreted in breast milk. If you are or will be breast-feeding while you are using Probalan, check with your doctor or pharmacist to discuss the risks to your baby.

Possible Side Effects

Check with your doctor if any of these most common side effects persist or become bothersome:

• dizziness; flushing; hair loss; headache; loss of appetite; nausea; sore gums; vomiting.

• severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blood in the urine; chills; dark urine; decreased or increased urination; fever; lower back, lower stomach, genital, or inner thigh pain; persistent sore throat; severe or persistent nausea, vomiting, or stomach pain; unusual bleeding or bruising; unusual tiredness or weakness; worsening gout; yellowing of the eyes or skin.

More Information

Probalan is to be used only by the patient for whom it is prescribed. Do not share it with other people.
If your symptoms do not improve or if they become worse, check with your doctor.